Antimicrobial resistance sub-study
Assessing the impact of routine prophylactic azithromycin use on bacterial colonisation and antimicrobial resistance across multiple body compartments.
The antimicrobial resistance (AMR) sub-study assesses bacterial colonisation and antimicrobial resistance across multiple body compartments.
Collaborator and co-lead: Dr Gert Marais, University of Cape Town
Study design and methods
Nasopharyngeal and oropharyngeal swabs, rectal swabs, urine and blood samples are collected at four key time points: baseline (prior to azithromycin exposure), week 4 (at discontinuation of azithromycin), week 24 (five months post discontinuation) and at hospitalisation.
This sampling schedule, combined with the selected microbiological methods, enables comprehensive analyses including phenotypic resistance testing and microbiome profiling.
Study population
The study aims to enrol 450 participants across six countries: South Africa, Zambia, Uganda, Nigeria, Ethiopia and Mozambique.
Recruitment and sample collection status
Dive into site-specific recruitment data to track performance and monitor progress. Use filters to sort by country, city, or site name.
Last updated date
2026-08-19
